Propagación de onda en un tejido cardiaco 3D usando dos modelos auriculares

Abstract

Objective to evaluate the degree of predictability between two models of human atrial cellular electrophysiology, analyzing at tissue level the properties of the action potential duration (APD) and conduction velocity (CV) in a three-dimensional tissue incorporating direction of fibers for the entire atrial anatomy. Methods we implemented the cellular models of Courtemanche-Ramirez-Nattel and Nygren, also developed a detailed and realistic geometric model of a human atrium, starting from the clumsy model of Harrild-Henriquez to which we incorporated the direction of fibers throughout the entire atrial anatomy. Results The diffusion constants implemented allowed to obtain in both models conduction velocities very similar to the real conduction velocities; moreover, in the high conductivity regions the longitudinal fiber direction allowed to obtain conduction velocities higher than in other areas of the atrium. Conclusions the action potential curve shows a APD90 (AP at 90% of repolarization) of 320 ms in NYG and 235 ms in CRN. Under conditions where the membrane properties have not changed in the normal atrium, we observed that in both models increases of fast action potential are generated, which can be seen as the potential associated with a low propagation velocity in the transversal direction and a slow rise of the action potential, which is also related to a high propagation velocity in the longitudinal direction.